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KMID : 1140220160210010001
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대한암예방학회지
2016 Volume.21 No. 1 p.1 ~ p.12
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The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention
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Huzefa Vahora
Munawwar Ali Khan
Usama Alalami
Arif Hussain
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Abstract
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Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in this regard still remains unanswered. This review summarizes the recent information on NO and its role in carcinogenesis and tumor progression, as well as dietary chemopreventive agents which have NO-modulating properties with safe cytotoxic profile. Understanding the molecular mechanisms and cross-talk modulating NO effect by these chemopreventive agents can allow us to develop better therapeutic strategies for cancer treatment.
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KEYWORD
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Chemoprevention, Nitric oxide, Inducible nitric oxide synthase, Endothelial nitric oxide synthase, Neoplasms
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